Takeshi Kitano
Research highlight
I am studying on environmental sex determination using the medaka Oryzias latipes (Fig.1), a teleost fish with an XX/XY sex determination system similar to mammals. I found that heat stress induces masculinization of XX medaka through cortisol elevation and PPARα activation (Fig.2). Future study will focus on roles of cortisol and PPARα in some cultured fish species.
Résumé
1999.09: PhD, Graduate School of Science & Technology, Kumamoto University
2000.04 - 2005.03: Assistant professor, Graduate School of Science &
Technology, Kumamoto University
2005.04 - 2019.08: Associate professor, Graduate School of Science &
Technology, Kumamoto University
2017.05 - 2017.10: Research fellows, Department of Biosciences, University
of Birmingham, UK
2019.09 - present: Professor, Graduate School of Science & Technology,
Kumamoto University
Contact information
Tel:
(+81) 096-342-3031
Email: tkitano(at)kumamoto-u.ac.jp
Address:
2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555 JAPAN
Kurokami South campus
Faculty of Science Building 1, Room C325
PhD., Professor
Animal molecular biology
Department of Molecular Agriculture
Select publications
Evaluation of 3β-hydroxysteroid dehydrogenase activity using progesterone
and androgen receptors-mediated transactivation. Takashi Yazawa, Yugo Watanabe,
Yuko Yokohama, Yoshitaka Imamichi, Kazuya Hasegawa, Ke-ichi Nakajima, Takeshi Kitano, Takanori Ida, Takahiro Sato, Mohammad Sayful Islam …. Frontiers in Endocrinology
15 2024/10/2
Diversity of Androgens; Comparison of Their Significance and Characteristics
in Vertebrate Species. Takashi Yazawa, Yoshitaka Imamichi, Takahiro Sato,
Takanori Ida, Akihiro Umezawa, Takeshi Kitano. Zoological science 41(1) 77-86 2024/2
Expression and functional analyses for estrogen receptor and estrogen related
receptor of Yesso scallop, Patinopecten yessoensis. Wenbin Gu, Tongchai
Thitiphuree, Yurika Otoki, Emily C. Marquez, Takeshi Kitano, Naoki Itoh, Kazue Nagasawa, Makoto Osada. The Journal of Steroid Biochemistry
and Molecular Biology 106302-106302 2023/3
Comparison of Placental HSD17B1 Expression and Its Regulation in Various
Mammalian Species. Takashi Yazawa, Mohammad Sayful Islam, Yoshitaka Imamichi,
Hiroyuki Watanabe, Kazuhide Yaegashi, Takanori Ida, Takahiro Sato, Takeshi Kitano, Shigenori Matsuzaki, Akihiro Umezawa …. Animals : an open access journal
from MDPI 13(4) 2023/2/10
Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent
stem cells. Takashi Yazawa, Yoshitaka Imamichi, Takeshi Kitano, Mohammad Sayful Islam, Md Rafiqul Islam Khan, Satoru Takahashi, Toshio
Sekiguchi, Nobuo Suzuki, Akihiro Umezawa, Junsuke Uwada. Scientific Reports
13(1) 1611-1611 2023/1/28
Amh/Amhr2 Signaling Causes Masculinization by Inhibiting Estrogen Synthesis
during Gonadal Sex Differentiation in Japanese Flounder (Paralichthys olivaceus).
Toshiya Yamaguchi, Takeshi Kitano. International Journal of Molecular Sciences 24(3) 2480-2480 2023/1/27
Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica).
Hiroyuki Inaba, Yuzo Iwata, Takashi Suzuki, Moemi Horiuchi, Ryohei Surugaya,
Shigeho Ijiri, Ai Uchiyama, Ryoko Takano, Seiji Hara, Takashi Yazawa, Takeshi
Kitano. International Journal of Molecular Sciences 24(1) 396-396 2022/12/26
Y-specific amh allele, amhy, is the master sex-determining gene in Japanese
flounder Paralichthys olivaceus. Ricardo Shohei Hattori, Keiichiro Kumazawa,
Masatoshi Nakamoto, Yuki Nakano, Toshiya Yamaguchi, Takeshi Kitano, Eiichi Yamamoto, Kanako Fuji, Takashi Sakamoto. Frontiers in Genetics
13 1007548 2022/9/16
Oxidative Stress Causes Masculinization of Genetically Female Medaka Without
Elevating Cortisol. Koki Mukai, Seiji Hara, Konosuke Sakima, Ryo Nozu,
Takashi Yazawa, Takeshi Kitano. Frontiers in Endocrinology 13 878286 2022/6/16
Roles of Gonadotropin Receptors in Sexual Development of Medaka. Takeshi Kitano, Tomoaki Takenaka, Hisanori Takagi, Yasutoshi Yoshiura, Yukinori Kazeto,
Toshiaki Hirai, Koki Mukai, Ryo Nozu. Cells 11(3) 2022/1/24
Analyses of Molecular Characteristics and Enzymatic Activities of Ovine
HSD17B3. Mohammad Sayful Islam, Junsuke Uwada, Junki Hayashi, Kei-Ichiro
Kikuya, Yuki Muranishi, Hiroyuki Watanabe, Kazuhide Yaegashi, Kazuya Hasegawa,
Takanori Ida, Takahiro Sato, Yoshitaka Imamichi, Takeshi Kitano, Yoshimichi Miyashiro, Rafiqul Islam Khan, Satoru Takahashi, Akihiro Umezawa,
Nobuo Suzuki, Toshio Sekiguchi, Takashi Yazawa. Animals : an open access
journal from MDPI 11(10) 2021/9/30
Profiles of 5alpha-reduced androgens in humans and eels: 5alpha-dihydrotestosterone
and 11-ketodihydrotestosterone are active androgens produced in eel gonads.
Yazawa T, Inaba H, Imamichi Y, Sekiguchi T, Uwada J, Suzuki N, Umezawa
A, Kitano T. Frontiers in Endocrinology 12 657360 2021/3
Gonadal expression profiles of sex-specific genes during early sexual differentiation
in Japanese eel Anguilla japonica. Hiroyuki Inaba, Seiji Hara, Moemi Horiuchi,
Shigeho Ijiri, Takeshi Kitano. Fisheries Science 87(2) 203-209 2021/3
11-Ketotestosterone is a major androgen produced in porcine adrenal glands
and testes. Takashi Yazawa, Takahiro Sato, Takahiro Nemoto, Sayaka Nagata,
Yoshitaka Imamichi, Takeshi Kitano, Toshio Sekiguchi, Junsuke Uwada, Mohammad Sayful Islam, Daisuke Mikami
…. The Journal of steroid biochemistry and molecular biology 210 105847-105847
2021/2/17
Cortisol induces masculinization of XX medaka through gonadal soma-derived
growth factor (GSDF) and anti-Müllerian hormone receptor type 2 (AMHR2).
Seiji Hara, Rie Sawamura, Takeshi Kitano. Fisheries Science 87(1) 85-91 2021/1