新留 琢郎

にいどめ たくろ Takuro Niidome
博士(理学) 生体材料、医用材料 教授
分子農学部門

研究紹介

シルクフィブロインはカイコから得られるタンパク質繊維で
、力学特性に優れ、酸素透過性、生分解性、生体適合性もある
ことから、医療材料としての応用が期待されています。私たちの
研究室ではシルクフィブロインを薬物の徐放材料、冠状動脈ステント、
細胞足場として応用しようと研究を進めています。

図:医用材料の原料してての繭


略歴

1994.03:九州大学 博士(理学)
1994.04 – 2004.03:長崎大学 工学部応用化学科 助教
2001.08 – 2002.07:ピッツバーグ大学 薬学部 訪問研究員
2004.04 – 2012.11:九州大学 大学院工学研究院 准教授
2012.12 – 現在:熊本大学 大学院先端科学研究部 教授

お問い合わせ

Tel:
096-342-3667

Email: niidome(at)kumamoto-u.ac.jp

Address:
〒860-8555
熊本県熊本市中央区黒髪2-39-1
黒髪南地区
工学部研究棟Ⅱ 807 号室

研究業績

The effect of degumming conditions on the functionality of silk fibroin films. Masaya Harada, Wei Xu, Yusuke Kambe, Tsunenori Kameda, Shoji Nagaoka, Makoto Sasaki, Takuro Niidome. Polymer Journal 2025/2/21

Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs. Junya Michibata, Yoshimasa Kawaguchi, Hisaaki Hirose, Akiko Eguchi, Sayaka Deguchi, Kazuo Takayama, Wei Xu, Takuro Niidome, Yoshihiro Sasaki, Kazunari Akiyoshi …. Bioconjugate Chemistry 2024/12/18

Bacterial membrane vesicles combined with nanoparticles for bacterial vaccines and cancer immunotherapy. Wei Xu, Sayo Maruyama, Akito Sato, Takuro Niidome. Colloids and surfaces. B, Biointerfaces 243 114125-114125 2024/11

Encapsulation of silver nanoplates into poly(lactic-co-glycolic) acid nanoparticles and the antibacterial activity against intracellular bacteria. Ryoko Nawata, Sayo Maruyama, Wei Xu, Takuro Niidome. Chemistry Letters 53(5) 2024/5/2

ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells. Shunsuke Yoshie, Masashi Kuriyama, Masashi Maekawa, Wei Xu, Takuro Niidome, Shiroh Futaki, Hisaaki Hirose. Genes to cells : devoted to molecular & cellular mechanisms 2024/4/10

Fluoride-treated rare earth-free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices. Hirotaka Watanabe, Wei Xu, Haruka Uno, Yuki Uraya, Masanori Kugita, Yoshihiro Komohara, Takuro Niidome, Makoto Sasaki, Ichiro Shimizu, Nobuyuki Fujita …. Journal of biomedical materials research. Part A 2024/1/18

Styrene Maleic Acid Polymer-Encapsulated Chlorophyll as a Stable Micellar Nanoprobe for Advanced Anticancer Photodynamic Therapy. Waliul Islam, Hiroyasu Tsutsuki, Azizur Rahman, Ayaka Harada, Tianli Zhang, Katsuhiko Ono, Rayhanul Islam, Foysal Hossen, Takuro Niidome, Tomohiro Sawa …. ACS Applied Polymer Materials 2023/12/8

Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics. Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa. Frontiers in Microbiology 14 2023年10月27日

<scp>Water‐soluble</scp> hyperbranched polymer with high curcumin content. Yusuke Nakayama, Yutaro Ito, Tsuyoshi Fukaminato, Wei Xu, Takuro Niidome, Seiji Kurihara, Sunnam Kim. Journal of Applied Polymer Science 2023/9/6

Disulfiram encapsulated in polymer nanoparticles ameliorates thioacetamide-induced liver injury. Wei Xu, Yuta Kadoya, Kaito Sennari, Waliul Islam, Tianli Zhang, Tomohiro Sawa, Fumika Akizuki, Hisaaki Hirose, Shiroh Futaki, Yukio Fujiwara, Yoshihiro Komohara, Takuro Niidome. Journal of Drug Delivery Science and Technology 104981-104981 2023/9

Modification of Silver Nanoplates with Cell-Binding Subunit of Bacterial Toxin and Their Antimicrobial Activity against Intracellular Bacteria. Ayaka Harada, Wei Xu, Katsuhiko Ono, Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome. ACS Applied Bio Materials 2023/3/27

Structural Determination of the Nanocomplex of Borate with Styrene–Maleic Acid Copolymer-Conjugated Glucosamine Used as a Multifunctional Anticancer Drug. Waliul Islam, Hiroyasu Tsutsuki, Katsuhiko Ono, Ayaka Harada, Kozo Shinozaki, Takuro Niidome, Jun Fang, Tomohiro Sawa. ACS Applied Bio Materials 5(12) 5953-5964 2022/12/8

A Model of Transcriptional Activation of DNA by Loosening of Chromatin Structure. Yuko T Sato, Daisuke Asai, Keiko Terada, Jeong-Hun Kang, Takeshi Mori, Takuro Niidome, Hideki Nakashima, Yoshiki Katayama. Chemistry Letters 51(12) 1109-1112 2022/12/5

Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors. Waliul Islam, Takuro Niidome, Tomohiro Sawa. Journal of Personalized Medicine 2022/11/28

Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors. Waliul Islam, Takuro Niidome, Tomohiro Sawa. Journal of Personalized Medicine 2022/11

Controlled Delivery of an Anti-Inflammatory Toxin to Macrophages by Mutagenesis and Nanoparticle Modification. Ayaka Harada, Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome. Nanomaterials 12(13) 2161-2161 2022/6/23

Photo-control of Cellular Uptake by the Selective Adsorption of Spiropyran Derivatives on Albumin. Mai Shinohara, Wei Xu, Sunnum Kim, Tsuyoshi Fukaminato, Takuro Niidome, Seiji Kurihara. Chemistry Letters 51(6) 594-597 2022/6/5

Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’. Makoto Sasaki, Wei Xu, Yuki Koga, Yuki Okazawa, Akira Wada, Ichiro Shimizu, Takuro Niidome. Materials 15(9) 3132-3132 2022/4/26

Tailored Structure and Antibacterial Properties of Silica-Coated Silver Nanoplates by Pulsed Laser Irradiation. Emi Takeda, Wei Xu, Mitsuhiro Terakawa, Takuro Niidome. ACS Omega 7(8) 7251-7256 2022/3/1

Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review. Wei Xu, Makoto Sasaki, Takuro Niidome. Pharmaceutics 14(3) 2022/2/24

Photochemical OFF/ON Cytotoxicity Switching by Using a Photochromic Surfactant with Visible Light Irradiation. Mai Shinohara, Yuya Ashikaga, Wei Xu, Sunnam Kim, Tuyoshi Fukaminato, Takuro Niidome, Seiji Kurihara. ACS omega 7(7) 6093-6098 2022/2/22

Novel photoluminescent gold complexes prepared at octanethiol-water interfaces: Control of optical properties by addition of silver ions. Mio Tameike, Takuro Niidome, Yasuro Niidome, Junichi Kurawaki. Bulletin of the Chemical Society of Japan 94(7) 1875-1881 2021/7

Epr‐effect enhancers strongly potentiate tumor‐targeted delivery of nanomedicines to advanced cancers: Further extension to enhancement of the therapeutic effect. Waliul Islam, Shintaro Kimura, Rayhanul Islam, Ayaka Harada, Katsuhiko Ono, Jun Fang, Takuro Niidome, Tomohiro Sawa, Hiroshi Maeda. Journal of Personalized Medicine 11(6) 2021/6

Drug release system controlled by photothermal effect of gold nanoparticles. Takuro Niidome. Yakugaku Zasshi 141(3) 327-332 2021/3/1

pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer. Yong Il Park, Seung Hae Kwon, Gibok Lee, Keiichi Motoyama, Min Woo Kim, Min Lin, Takuro Niidome, Jung Hoon Choi, Ruda Lee. Journal of Controlled Release 330 1-14 2021/2/10

Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis. Waliul Islam, Yoshitaka Matsumoto, Jun Fang, Ayaka Harada, Takuro Niidome, Katsuhiko Ono, Hiroyasu Tsutsuki, Tomohiro Sawa, Takahisa Imamura, Kazuo Sakurai …. Biomaterials 269 2021/2

Near-infrared light and metallic nanoparticles. Wei Xu, Takuro Niidome. Drug Delivery System 36(3) 192-197 2021